Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate)是羟肟酸类HDAC选择性抑制剂，具有抗炎活性，对多发性骨髓瘤和急性髓性白血病细胞具有细胞毒性。近期，Givinostat在杜氏肌营养不良症III期临床试验中取得积极的积极的数据。

参考文献

[1] Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15.

[2] Golay J, et al. The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells. Leukemia. 2007 Sep;21(9):1892-900.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。