Fostamatinib Disodium (R788, Tamatinib Fosdium)，又称福他替尼二钠盐，R406的亚甲基磷酸盐药物前体，可在体内快速转化为R406，是Syk选择性抑制剂，IC₅₀值为41 nM，能抑制BCR信号，阻碍B细胞增殖。此外，R788相对于R406具有更好的药效性能和生物利用率。

参考文献

1. Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273.
2. Suljagic M, et al. The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood. 2010 Dec 2;116(23):4894-905.
3. Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。