PKI 14-22 amide, myristoylated是一种PKA抑制剂，它在N-端被肉豆蔻化，使其细胞的通透性增强。该肽的非肉豆蔻化版本是cAMP依赖性蛋白激酶的高度特异性抑制剂(Ki=36 nM)。HH-89和PKI (14-22) amide可降低IgG介导的吞噬反应。 

参考文献

[1] Ydrenius L1, Majeed M, et, al. Activation of cAMP-dependent protein kinase is necessary for actin rearrangements in human neutrophils during phagocytosis. J Leukoc Biol. 2000 Apr;67(4):520-8.

[2] Swierczewski BE, Davies SJ. Developmental regulation of protein kinase A expression and activity in Schistosoma mansoni. Int J Parasitol. 2010 Jul;40(8):929-35 Chemical Properties.

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