NU7441 (NU-7441; KU57788; KU-57788)是一种高效的、选择性的DNA-PK抑制剂，其IC₅₀值为14 nM，也会抑制mTOR和PI3K，其IC₅₀值分别为1.7 μM和5 μM。NU7441可抑制NHEJ通路，增强Cas9介导DNA剪接后发生的同源重组修复率。

参考文献

[1] Hardcastle I R, et al. Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach. Journal of medicinal chemistry, 2005, 48(24): 7829-7846.

[2] Zhao Y, et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer research, 2006, 66(10): 5354-5362.

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