Mitoxantrone米托蒽醌 拓扑异构酶II抑制剂/PKC抑制剂|CAS 65271-80-9（53342ES）

Mitoxantrone (Mitozantrone) 米托蒽醌是一种具有抗肿瘤活性的蒽二酮类抗生素，也是拓扑异构酶II抑制剂（topoisomerase II抑制剂），可插入DNA并使其交联，从而破坏DNA和RNA的复制，也可以与拓扑异构酶II结合，导致DNA链断裂和DNA修复抑制，还可抑制蛋白激酶C (PKC)。

参考文献

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[3]. Herman EH, et al. Comparison of the structural changes induced by doxorubicin and mitoxantrone in the heart, kidney and intestine and characterization of the Fe(III)-mitoxantrone complex. J Mol Cell Cardiol. 1997 Sep;29(9):2415-30.

[4]. Oudard S, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34.

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