Smoothened Agonist (SAG)，是一种有效的Smo受体激动剂，能够活化Hedgehog信号通路，K_d值为59 nM，EC₅₀值为3 nM。Hedgehog信号通路受体Smo蛋白通过调节Gli转录因子，在胚胎发育和组织稳态中发挥重要作用。

参考文献

1. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.
2. Guerrini G, et al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec;233(12):9799-9811.
3. Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Jun;139(6):1385-1396.
4. Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res. 2017 Jan 20;109(1):49-54.

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