重组人CD27/TNFRSF7(hFc标签)蛋白|Human CD27/TNFRSF7（93586ES）

CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. Mature human CD27 consists of a 172 amino acid (aa) extracellular domain (ECD) with three TNFR cysteine-rich repeats, a 21 aa transmembrane segment, and a 48 aa cytoplasmic domain. Within the ECD, human CD27 shares 63% and 66% aa sequence identity with mouse and rat CD27, respectively. CD27 is expressed as a disulfide-linked homodimer that carries N-linked and O-linked glycosylation. Proteolytic cleavage of CD27 results in the shedding of a 28-32 kDa fragment of the ECD. CD27 is weakly expressed on naive T cells and NK cells and is up-regulated upon cell activation. It is also up-regulated on activated germinal center B cells, plasma cells, and a subset of memory B cells. CD27 binds to the transmembrane glycoprotein CD27 Ligand/CD70 which is expressed on activated B cells, activated T cells, and dendritic cells.

高纯度、高活性、低内毒素、高批间一致性

产品数据

-25 ~ -15℃保存，收到货之后有效期1年。 复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。