HO-3867 (HO3867; HO 3867)是一种新型合成的二芳基烯基哌啶酮(DAP)化合物,是一种姜黄素类似物,也是STAT3抑制剂,抑制STAT3的磷酸化、转录和DNA结合活性,而不影响其他活性STATs的表达。HO-3867对多种肿瘤细胞具有抑制增殖、迁移、侵袭和促进凋亡的作用,如卵巢癌、子宫内膜癌、胰腺癌等,具有良好的抗肿瘤特性。
参考文献
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冰袋运输。粉末直接保存于-25~-15℃,有效期2年。建议干燥保存,避免反复冻融。