PD153035（SU-5271; AG1517; NSC 669364; ZM 252868）是一种高效的、特异性的EGFR抑制剂（表皮生长因子受体抑制剂），竞争性地结合ATP位点，从而抑制EGFR的酪氨酸激酶活性，其IC₅₀值为25 pM，Ki值为5.2 pM。

参考文献

[1] Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106.

[2] Kunkel MW1, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302.

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