Lomvastomig 是一种抗 PDCD1/HAVCR2 的人源 IgG1 κ 单克隆抗体。Lomvastomig 的同型对照产品：Human IgG1 kappa, Isotype Control。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

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The detected molecular weight of Anti-PD-1 & TIM-3 Reference Antibody (Lomvastomig) is 145.11 kDa.

Anti-PD-1 & TIM-3 Reference Antibody (Lomvastomig) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

The purity of Anti-PD-1 & TIM-3 Reference Antibody (Lomvastomig) is 90.00%, determined by SEC-HPLC.

Lomvastomig bound to PD-1 protein, and then rebounded to secondary antibodies(Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Lomvastomig bound to hu-PD-1-His, and the EC50 was 0.014 nM.

Lomvastomig bound to TIM-3 protein, and then rebounded to secondary antibodies(Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Lomvastomig bound to hu-TIM-3-His, and the EC50 was 0.933 nM.

Lomvastomig bound to huPD-1-Jurkat cells, and then rebounded to fluorescent secondary antibodies(Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Lomvastomig bound to huPD-1-Jurkat cells, and the EC50 was 1.788 nM.

Lomvastomig bound to huTIM3-FL-HEK293 cells, and then rebounded to fluorescent secondary antibodies(Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Lomvastomig bound to huTIM3-FL-HEK293 cells, and the EC50 was 239.100 nM.

Co-incubation of Lomvastomig with PD-1-NF-AT-Jurkat and CD3L-huPD-L1-CHO-K cells and incubated for 6 hours. Bright-Lite was used to detect the fluorescent signal. As shown in fig, Lomvastomig was able to block the PD-1/PD-L1 signaling pathway, and the EC50 was 4.300 nM.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.