Ubamatamab (REGN4018) 是一种靶向粘蛋白 16 (MUC16) 和 CD3 的人源化双特异性抗体。Ubamatamab 表现出有效的抗肿瘤活性。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

本产品仅用作科学研究！

The detected molecular weight of Anti-CA125 & CD3 Reference Antibody (Ubamatamab) is 144.40 kDa.

Anti-CA125 & CD3 Reference Antibody (Ubamatamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

The purity of Anti-CA125 & CD3 Reference Antibody (Ubamatamab) is 100.00%, determined by SEC-HPLC.

Ubamatamab bound to OVCAR3 cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE), and test by flow cytometry. As shown in fig, Ubamatamab bound to OVCAR3 cells, and the EC50 was 0.381 nM.

Ubamatamab bound to huCD3e-jurkat cells, and then rebounded to fluorescent secondary antibodies(Anti-Human IgG, Fcγ PE), and test by flow cytometry. As shown in fig, Ubamatamab bound to huCD3e-jurkat cells, and the EC50 was 6.845 nM.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.