分子生物学
IVD分子诊断
细胞培养与分析
蛋白研究
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重组蛋白
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高通量测序建库
病原检测UCF系列
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Anti-TROP2 Reference Antibody (Sacituzumab-MMAE)
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产品介绍
Sacituzumab 是一种人源化靶向滋养细胞表面抗原 2 (TROP2) 的 IgG1 单克隆抗体。Sacituzumab 单独使用缺乏抗肿瘤作用,在肿瘤转移过程中并不抑制 TROP-2 的功能,能与 TROP-2 蛋白的线性表位结合。Sacituzumab 可用于抗体-药物偶联物 (ADC) 药物 Sacituzumab govitecan的合成。Sacituzumab govitecan 可被用于三阴性乳腺癌领域。
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For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.
应用案例

本产品仅用作科学研究!


Anti-TROP2 Reference Antibody (Sacituzumab-MMAE) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%.

The purity of Anti-TROP2 Reference Antibody (Sacituzumab-MMAE) is more than 95%, determined by SEC-HPLC.

Sacituzumab-ADC inhibited the tumor growth of MDA-MB-231 on NSG mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 80.0% at 5 mpk at D37.

Killing assay test on NCL-H292 Cells,the maximum kill rate of anti-TROP2 Reference Antibody (Sacituzumab MMAE) is about 100%.

存储条件
-80°C for 2 years under sterile conditions;-20°C for 1 year under sterile conditions;Avoid repeated freeze-thaw cycles.
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