Zilovertamab (UC-961) 是一种人源化抗 ROR1 单克隆抗体，可阻断 Wnt5a 诱导的 ROR1 信号通路。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

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Anti-ROR1 Reference Antibody (zilovertamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

The purity of Anti-ROR1 Reference Antibody (zilovertamab vedotin) is 98.21%, determined by SEC-HPLC.

Immobilized human ROR1 His at 2 ug/mL can bind Anti-ROR1 Reference Antibody (zilovertamab vedotin), EC50=0.002833 ug/mL.

Human ROR1 HEK293T cells were stained with Anti-ROR1 Reference Antibody (zilovertamab vedotin) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.05656 ug/ml.

zilovertamab vedotin inhibited the tumor growth of MDA-MB-231on NSG mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 96.6% at 10 mpk.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.