IMC-EB10 是一种抗 FLT3 单克隆抗体。IMC-EB10 能够高亲和力 (Kd = 158 pM) 结合 FLT3，并阻断 FLT3 配体与 FLT3 的结合 (IC50 ≈ 10 nM)，进而抑制白血病细胞中的 MAPK、STAT5 和 PI3K/Akt 信号传导。IMC-EB10 可以增强 Methotrexate 抗白血病的效果，抑制表达野生型或 ITD 突变型 FLT3 受体的白血病。IMC-EB10 延长急性淋巴细胞白血病 (ALL) 细胞系和原发性白血病样本的生存期并减少非肥胖糖尿病/严重联合免疫缺陷的植入。IMC-EB10 可用于白血病研究。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

本产品仅用作科学研究！

Anti-FLT3 / CD135 Reference Antibody (IMC-EB10) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%.

The purity of Anti-FLT3 / CD135 Reference Antibody (IMC-EB10) is more than 95%, determined by SEC-HPLC.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.