HPN536 是一种三特异性 T 细胞活化蛋白构建体，可与表达间皮素的肿瘤细胞、T 细胞上的 CD3ε 和血清白蛋白结合。HPN536 特异性重定向T细胞，以强效重定向裂解表达间皮素的癌细胞，同时激活 T 细胞。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

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The detected molecular weight of Anti-CD3e & Mesothelin & Serum Albumin Reference Antibody (Hpn536) is 52.90 kDa.

Anti-CD3e & Mesothelin & Serum Albumin Reference Antibody (Hpn536) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

The purity of Anti-CD3e & Mesothelin & Serum Albumin Reference Antibody (Hpn536) is 100.00%, determined by SEC-HPLC.

Hpn536 bound to MSLN protein, and then rebounded to secondary antibodies(Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Hpn536 bound to huMSLN-Fc, and the EC50 was 0.374 nM.

Hpn536 bound to MSLN protein, and then rebounded to secondary antibodies(Anti-6*his-HRP ) , and read OD450. As shown in fig, Hpn536 bound to HSA-Fc, and the EC50 was 0.061 nM.

Co-incubation of Hpn536 with Jurkat cells, then with the addition of CHOK1-MSLN cells for 6 hours. Bright-Lite was used to detect the fluorescent signal. As shown in fig, Hpn536 was able to activate the NF-AT signaling pathway, and the EC50 was 0.033 nM.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.