Etaracizumab 是一种 αvβ3 整合素 IgG 单克隆抗体。Etaracizumab 旨在通过 NK 细胞介导的细胞毒作用靶向作用于 αvβ3+ 癌细胞。Etaracizumab 在空间上阻碍大配体进入 RGD 结合位点，但不会阻断该位点。Etaracizumab 在体外降低 p-Akt。Etaracizumab 可以降低癌细胞的增殖和侵袭能力。Etaracizumab 诱导肿瘤细胞凋亡，并抑制 αvβ3 介导的细胞粘附、内皮细胞迁移和破骨细胞介导的骨吸收。Etaracizumab 可用于卵巢癌、转移性黑色素瘤以及晚期实体瘤等癌症的抗肿瘤研究。推荐同型对照：Human IgG1 kappa, Isotype Control。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

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Anti-Integrin aVb3 (ITGAV & ITGB3) Reference Antibody (etaracizumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 90%.

The purity of Anti-Integrin aVb3 (ITGAV & ITGB3) Reference Antibody (etaracizumab) is more than 95%, determined by SEC-HPLC.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.