Tilvestamab (BGB149) 是一种人源化抗 AXL 抗体，阻断 AXL 介导的细胞信号传导。Tilvestamab 在体外能显著抑制 Gas6 刺激诱导的 AXL 激活，并抑制 786-0-Luc RCC 细胞中下游 AXL 的磷酸化。Tilvestamab可用于癌症，尤其是 AXL 过度表达肾细胞癌的研究。

For Powder, reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

本产品仅用作科学研究！

Anti-AXL / UFO Reference Antibody (tilvestamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

The purity of Anti-AXL / UFO Reference Antibody (tilvestamab) is more than 95%, determined by SEC-HPLC.

Immobilized human Axl FC at 2 ug/mL can bind Anti-AXL / UFO Reference Antibody (tilvestamab), EC50=0.01542 ug/mL.

Human AXL HEK293 cells were stained with Anti-AXL / UFO Reference Antibody (tilvestamab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC50=0.07318 ug/mL.

The endocytosis ratio tilvestamab by U251 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 40% at antibody concentration of 1 nM.

-80°C for 2 years under sterile conditions；-20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles.