Silymarin是从水飞蓟中提取的活性成分，能够有效抑制SARS-CoV-2主蛋白酶活性。该化合物可显著抑制肿瘤细胞增殖与血管生成，并改善胰岛素抵抗状态，对肝细胞癌具有化学预防作用，在COVID-19及肿瘤防治研究中展现出潜在应用价值。

[1] Féher J, Lengyel G. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13(1):210-7. doi: 10.2174/138920112798868818. PMID: 21466434. [2] Khoshnoodi M, Fakhraei N, Dehpour AR. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. Pharm Biol. 2015 May;53(5):739-45. doi: 10.3109/13880209.2014.942787. Epub 2014 Nov 28. PMID: 25431050.