MK2-IN-1是一种有效且选择性的MAPKAPK2抑制剂。该化合物可降低Tfcp2l1蛋白中丝氨酸残基的磷酸化水平。[1]

[1] Zhang Y, Ding H, Wang X, Wang X, Wan S, Xu A, Gan R, Ye SD. MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal. Cell Rep. 2021 Nov 2;37(5):109949. doi: 10.1016/j.celrep.2021.109949. PMID: 34731635.