RO5126766(RG-7304/CKI27) MEK/RAF抑制剂|CAS 946128-88-7（54570ES）

RO5126766是MEK/RAF抑制剂，抑制RAF磷酸化MEK1蛋白和MEK1活化ERK2蛋白，作用于BRAF、CRAF和MEK1的IC₅₀值为19 nM、56 nM和160 nM。

参考文献

[1] Ishii N, Harada N, Joseph EW, et al. Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity. Cancer Res. 2013 Jul 1;73(13):4050-4060. doi: 10.1158/0008-5472.CAN-12-3937(IF:8.378).

[2] Wada M, Horinaka M, Yamazaki T, et al. The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells. PLoS One. 2014 Nov 25;9(11):e113217. doi: 10.1371/journal.pone.0113217(IF:2.776).

-25~-15℃保存，有效期3年。