TA-02 (TA02)是SB 203580的2,4,5-三取代唑类类似物，是p38 MAPK的抑制剂，IC₅₀值为20 nM。TA-02作用于p38α和CK1δ/ε，IC₅₀值分别为20、32和32nM。TA-02可诱导人胚胎干细胞分化为心肌细胞。

参考文献

1.Laco F, et al. Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J Mol Cell Cardiol. 2015 Mar;80:56-70.

2.Jiedong Liang, et al. The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. Exp Ther Med. 2019 Mar;17(3):1688-1696.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。