Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.Functions as a receptor for Pseudomonas aeruginosa exotoxin A.

WB: 1/500-1/1000  IHC: 1/50-1/100

Western blot

Western blot analysis of LRP1 in mouse brain lysates using LRP1 antibody.

Western blot analysis of LRP1 in rat Brain, C6 lysates using LRP1 antibody

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using LRP1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunocytochemistry

Immunocytochemistry analysis of LRP1 (green) in U87-MG using LRP1 antibody,and DAPI(blue).

-15到-25度