Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.Calcium is required for ligand binding.

Western

Western blot analysis of ASGPR in lysates of HepG2 and Human liver using ASGPR antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human liver using ASGPR antibody.High pressure and temperature Tris/EDTA (PH 9.0) used for antigen retrieval.The brown color represents the positive signal observed with ASGPR antibody.

Immunocytochemistry

Immunocytochemistry analysis of ASGPR(green) in HepG2 cell line using ASGPR antibody,and DAPI(blue).

Flow

Flow Cytometry analysis of HepG2 cell line stained with ASGPR antibody(Red).Blue line histogram represents nonspecific negative control