The NF-κB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IκB proteins. Most agents that activate NF-κB do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of IκB.

Western

Western blot analysis of IKK gamma in Jurkat lysates using IKK gamma antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded mouse colon using IKK gamma antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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