Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Western

Western blot analysis of AKR7A2 in lysates of HeLa,293,TT and JurKat using AKR7A2 antibody.

Immunocytochemistry

Immunocytochemistry analysis of AKR7A2(green) in Jurkat cell line using AKR7A2 antibody,and DAPI(blue).

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。