May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit .

Western

Western blot analysis of IRS1 in 293 lysates using IRS1 antibody.

Western

Western blot analysis of IRS1 in HEK293 lysates using IRS1 antibody.