Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.

Western

Western blot analysis of HuR in 293 lysates using HuR antibody.

Western

Western blot analysis of HuR in Jurkat ，mouse heart，rat spleen lysates using HuR antibody.

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