This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.

Western

Western blot analysis of GRP75 in A549 (1), PANC-1 (2), PC-12 (3), C6 (4), CSO-7 (5)and NIH3T3 (6) cell lysate using GRP75 antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded human rectal cancer tissues using GRP75 antibody.

Immunocytochemistry

Immunocytochemistry analysis of GRP75 in Hela cells using GRP75 antibody (green),and DAPI(blue). Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Flow

Flow Cytometry analysis of HepG2 cells using GRP75 antibody (green) and negative control (red).