This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded human bladder cancer tissues using CD47 antibody.

Immunocytochemistry

Immunocytochemistry analysis of CD47 in Hela cells using CD47 antibody (green),and DAPI(blue). Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Flow

Flow Cytometry analysis of K562 cells using CD47 antibody (green) and negative control (red).