Plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKα), which causes conformational changes, resulting in kinase activation.

Western

Western blot analysis of IKK alpha in Daudi lysates using IKK alpha antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded mouse kidney using IKK alpha antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Western

Western blot analysis of IKKα in Jurkat and K562 lysates using IKKα antibody