Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Western

Western blot analysis of TIA1 in Molt4 lysates using TIA1 antibody.

Western

Western blot analysis of TIA1 in (1) Jurkat lysates; (2) NIH/3T3 lysates using TIA1 antibody.