Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

Western

Western blot analysis of Cleaved- PARP in Jurkat and Hela lysates using Cleaved-PARP1 antibody.

Western

Western blot analysis of Cleaved- PARP in Jurkat lysates using Cleaved-PARP1 antibody.

Immunofluorescence

Immunofluorescence analysis of Cleaved-PARP1 in HeLa using Cleaved- PARP antibody.