ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.

Western

Western blot analysis of ATP citrate lyase in HeLa lysates using ATP Citrate lyase antibody.

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human brain carcinoma using ATP citrate lyase antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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