Teprotumumab 是一种靶向胰岛素样生长因子-1受体（IGF-1R）的人源单克隆抗体，可通过特异性结合该受体细胞外α亚基的配体结合结构域，阻断其活性，能够抑制成纤维细胞中TSH与IGF-1的信号传导，降低TSH依赖的IL-6、IL-8表达水平并抑制Akt磷酸化。

Purity:SDS-PAGE

Anti-IGF1R / CD221 Reference Antibody (teprotumumab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.

Purity:SEC-HPLC

The purity of Anti-IGF1R / CD221 Reference Antibody (teprotumumab) is 96.97%, determined by SEC-HPLC.

Bioactivity:ELISA

Immobilized human IGF1R His at 2 ug/mL can bind Anti-IGF1R / CD221 Reference Antibody (teprotumumab), EC50=0.009199 ug/mL.

Bioactivity:FACS

Human IGF1R CHO-K1 cells were stained with Anti-IGF1R / CD221 Reference Antibody (teprotumumab) and negative control protein respectively, washed and then followed by APC and analyzed with FACS, EC50=0.1968 nM.

-25~-15℃保存，有效期1年。