Phenacetin作为一种非阿片类解热镇痛化合物，可通过选择性抑制环氧化酶-3（COX-3）发挥止痛作用。该药物在代谢研究中常作为人肝微粒体及大鼠体内CYP1A2酶活性的特异性探针使用。
|
英文别名 (English Synonym) |
Phenacetin |
|
中文名称 (Chinese Name) |
非那西丁 |
|
靶点 (Target) |
COX |
|
通路 (Pathway) |
Neuroscience |
|
CAS号 (CAS NO.) |
62-44-2 |
|
分子式 (Formula) |
C10H13NO2 |
|
分子量 (Molecular Weight) |
179.22 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, Simmons DL. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. doi: 10.1073/pnas.162468699. Epub 2002 Sep 19. PMID: 12242329; PMCID: PMC129799. [2] He XM, Zhou Y, Xu MZ, Li Y, Li HQ, Li WY. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct;7(10):1725-31. doi: 10.3978/j.issn.2072-1439.2015.10.07. PMID: 26623094; PMCID: PMC4635270.
