Gimeracil作为口服氟嘧啶类衍生物S-1的组成成分，具有双重作用机制：该化合物不仅能有效抑制二氢嘧啶脱氢酶的活性，还可阻断DNA双链断裂的修复过程。
|
英文别名 (English Synonym) |
Gimeracil |
|
中文名称 (Chinese Name) |
吉美嘧啶；吉莫斯特 |
|
靶点 (Target) |
Dehydrogenase |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
103766-25-2 |
|
分子式 (Formula) |
C5H4ClNO2 |
|
分子量 (Molecular Weight) |
145.54 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Takagi M, Sakata K, Someya M, Tauchi H, Iijima K, Matsumoto Y, Torigoe T, Takahashi A, Hareyama M, Fukushima M. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug;96(2):259-66. doi: 10.1016/j.radonc.2010.05.020. Epub 2010 Jun 26. PMID: 20584556. [2] Fukushima M, Sakamoto K, Sakata M, Nakagawa F, Saito H, Sakata Y. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo. Oncol Rep. 2010 Nov;24(5):1307-13. doi: 10.3892/or_00000987. PMID: 20878125.
