贝曲西班（PRT054021）是一种口服有效的高选择性Xa因子（fXa）抑制剂，其IC50值为1.5 nM，通过抑制fXa发挥强效抗血栓形成作用。
|
英文别名 (English Synonym) |
Betrixaban |
|
中文名称 (Chinese Name) |
贝曲西班 |
|
靶点 (Target) |
Factor Xa |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
330942-05-7 |
|
分子式 (Formula) |
C23H22ClN5O3 |
|
分子量 (Molecular Weight) |
451.91 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Zhang P, Huang W, Wang L, Bao L, Jia ZJ, Bauer SM, Goldman EA, Probst GD, Song Y, Su T, Fan J, Wu Y, Li W, Woolfrey J, Sinha U, Wong PW, Edwards ST, Arfsten AE, Clizbe LA, Kanter J, Pandey A, Park G, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY. Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2179-85. doi: 10.1016/j.bmcl.2009.02.111. Epub 2009 Mar 3. PMID: 19297154.
