甲磺酸沙奎那韦（Ro 31-8959）是一种口服有效的人类免疫缺陷病毒（HIV）蛋白酶抑制剂，用于艾滋病的研究；该药物还具有抗炎活性，并能诱导人红细胞凋亡。
|
英文别名 (English Synonym) |
Saquinavir mesylate |
|
中文名称 (Chinese Name) |
沙奎那韦甲磺酸盐 |
|
靶点 (Target) |
HIV Protease |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
149845-06-7 |
|
分子式 (Formula) |
C39H54N6O8S |
|
分子量 (Molecular Weight) |
766.95 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Waibel S, Bissinger R, Bouguerra G, Abbès S, Lang F. Saquinavir Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2015;37(5):1973-82. doi: 10.1159/000438558. Epub 2015 Nov 20. PMID: 26584296.[2]Pettoello-Mantovani M, Kollmann TR, Raker C, Kim A, Yurasov S, Tudor R, Wiltshire H, Goldstein H. Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues. Antimicrob Agents Chemother. 1997 Sep;41(9):1880-7. doi: 10.1128/AAC.41.9.1880. PMID: 9303378; PMCID: PMC164029.
