酮康唑（R-41400）是一种咪唑类抗真菌药物，同时也是细胞色素P450酶家族中CYP3A4和CYP24A1的经典抑制剂。
|
英文别名 (English Synonym) |
Ketoconazole |
|
中文名称 (Chinese Name) |
酮康唑 |
|
靶点 (Target) |
P450 |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
65277-42-1 |
|
分子式 (Formula) |
C26H28Cl2N4O4 |
|
分子量 (Molecular Weight) |
531.43 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Seif El-Din SH, Abdel-Aal Sabra AN, Hammam OA, El-Lakkany NM. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51(2):165-75. doi: 10.3347/kjp.2013.51.2.165. Epub 2013 Apr 25. PMID: 23710083; PMCID: PMC3662059.[2]Seif El-Din, S. H., Al-Hroob, A. M., & Ebeid, F. A. (2016). P-glycoprotein expression and its role in the resistance of Schistosoma mansoni to praziquantel. PLOS ONE, 11(3), e0152545.
