Amodiaquine dihydrochloride是一种4-氨基喹啉类口服抗疟剂，可有效抑制组胺N-甲基转移酶，并作为Nurr1受体激动剂通过结合其配体结合域发挥抗炎作用。
| 英文别名 (English Synonym) | Amodiaquine dihydrochloride dihydrate |
| 中文名称 (Chinese Name) | 阿莫地喹盐酸盐 |
| 靶点 (Target) | Transferase |
| 通路 (Pathway) | Protease/Metabolic Enzyme |
| CAS号 (CAS NO.) | 6398-98-7 |
| 分子式 (Formula) | C20H28Cl3N3O3 |
| 分子量 (Molecular Weight) | 464.81 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, Nguyen QT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, Tu Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, Kim KS. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. doi: 10.1073/pnas.1509742112. Epub 2015 Jun 29. PMID: 26124091; PMCID: PMC4507186.
[2] Kinoshita K, Matsumoto K, Kurauchi Y, Hisatsune A, Seki T, Katsuki H. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. doi: 10.1016/j.jneuroim.2019.02.010. Epub 2019 Feb 22. PMID: 30825859.
