AKBA (Acetyl-11-keto-β-boswellic acid)是从乳香中提取的活性成分，作为一种新型的核因子E2相关因子2（Nrf2）通路激活剂，具有调节氧化应激反应和细胞防御机制的作用。
|
英文别名 (English Synonym) |
AKBA |
|
中文名称 (Chinese Name) |
3-乙酰基-11-酮基-β-乳香酸 |
|
靶点 (Target) |
5-Lipoxygenase |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
67416-61-9 |
|
分子式 (Formula) |
C32H48O5 |
|
分子量 (Molecular Weight) |
512.7 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Park YS, Lee JH, Harwalkar JA, Bondar J, Safayhi H, Golubic M. Acetyl-11-keto-beta-boswellic acid (AKBA) is cytotoxic for meningioma cells and inhibits phosphorylation of the extracellular-signal regulated kinase 1 and 2. Adv Exp Med Biol. 2002;507:387-93. doi: 10.1007/978-1-4615-0193-0_60. PMID: 12664615. [2] Banji D, Banji OJF, Rashida S, Alshahrani S, Alqahtani SS. Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model. J Ethnopharmacol. 2022 Jun 28;292:115200. doi: 10.1016/j.jep.2022.115200. Epub 2022 Mar 17. PMID: 35306043.
