Sulfaphenodium作为一种选择性人CYP2C9酶抑制剂，具有多重生物活性：该化合物能通过抑制光诱导的坏死和线粒体应激引发的凋亡途径，有效保护光感受器免受光损伤；其抗菌机制涉及增强M1型巨噬细胞活性；在心血管方面，该药物可显著缩小梗死面积并促进缺血再灌注后的冠状动脉血流恢复。
|
英文别名 (English Synonym) |
Sulfaphenazole |
|
中文名称 (Chinese Name) |
磺胺苯吡唑 |
|
靶点 (Target) |
P450 |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
526-08-9 |
|
分子式 (Formula) |
C15H14N4O2S |
|
分子量 (Molecular Weight) |
314.4 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Chang Q, Berdyshev E, Cao D, Bogaard JD, White JJ, Chen S, Shah R, Mu W, Grantner R, Bettis S, Grassi MA. Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. J Biol Chem. 2014 Mar 21;289(12):8337-52. doi: 10.1074/jbc.M113.507152. Epub 2014 Feb 11. PMID: 24519941; PMCID: PMC3961660. [2] Elmi S, Sallam NA, Rahman MM, Teng X, Hunter AL, Moien-Afshari F, Khazaei M, Granville DJ, Laher I. Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice. Vascul Pharmacol. 2008 Jan;48(1):1-8. doi: 10.1016/j.vph.2007.09.001. Epub 2007 Sep 15. PMID: 17974492.
