Salirasib，又称法尼基硫代水杨酸，是PPMTase抑制剂，是竞争性的Ras抑制剂，是一种法尼基半胱氨酸模拟物，可选择性地破坏活性Ras蛋白与质膜的结合，抑制Ras甲基化，具有抗肿瘤活性。Ras在多种肿瘤中处于活化状态，参与调节多种细胞过程，包括细胞生长、分化和细胞死亡。

参考文献

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[2] Makovski V, Haklai R, Kloog Y. Farnesylthiosalicylic acid (salirasib) inhibits Rheb in TSC2-null ELT3 cells: a potential treatment for lymphangioleiomyomatosis. Int J Cancer. 2012 Mar 15;130(6):1420-9. doi: 10.1002/ijc.26139(IF:4.982).

[3] Nevo Y, Aga-Mizrachi S, Elmakayes E, et al. The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. PLoS One. 2011 Mar 22;6(3):e18049. doi: 10.1371/journal.pone.0018049(IF:2.776).

-25~-15℃保存，有效期3年。