ABC294640 (Opaganib, ABC-294640)是鞘氨醇激酶2(SK2)选择性抑制剂，IC₅₀值为60 μM；ABC294640与鞘氨醇竞争性结合SK2的鞘氨醇结合位点，K_i为9.8 μM，具有抗肿瘤活性。

参考文献

[1] French KJ, et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.

[2] Beljanski V, et al. A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther. 2010 May;333(2):454-64.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议分装后-25~-15℃干燥保存，避免反复冻融。