Eragidomide (CC-90009, CC90009)是一种新型cereblon (CRBN) E3连接酶调节剂，CC-90009与CRL4^CRBN结合选择性靶向GSPT1以进行泛素化和蛋白酶体降解。GSPT1是一种小的GTPase，它与翻译终止因子eRF1形成复合物以介导翻译终止。Eragidomide通过促进GSPT1降解可快速诱导急性髓系白血病(AML)细胞凋亡。

参考文献

[1] Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677.

[2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64(4):1835-1843.

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