PAC-1 (PAC1, Procaspase activating compound 1)，又称半胱天冬酶原活化物1，是邻羟基N-酰基肼化合物，是一种有效的procaspase-3（酶原-3）激活剂，直接催化成熟的procaspase-3分裂成为有活性的caspase-3，对多种癌细胞具有细胞毒性。

参考文献

1.Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8(8):1640-52.

2.Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1). Cell Death Dis. 2013 Dec 19;4:e968.

3.Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2(10):543-50.

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