Dorsomorphin (Compound C, BML-275, BML275)是一种可逆的AMPK选择性抑制剂，K_i为109 nM，可诱导自噬。Dorsomorphin是BMP I型受体ALK2/3/6的抑制剂，下调BMP信号活性，并促进人多能干细胞(hPSC)的神经分化。

参考文献

[1].Zhou G, et al. Role of AMP-activated protein kinase in mechanism of action. J Clin Invest. 2001 Oct;108(8):1167-74.

[2].Kim YM, et al. Compound C independent of AMPK inhibits ICAM-1 and VCAM-1 expression in inflammatory stimulants-activated endothelial cells in vitro and in vivo. Atherosclerosis. 2011 Nov;219(1):57-64.

[3].Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.

[4].Guo Y, et al. AMPK inhibition blocks ROS-NFκB signaling and attenuates endotoxemia-induced liver injury. PLoS One. 2014 Jan 24;9(1):e86881.

冰袋运输。粉末直接保存于-25~-15℃，有效期3年。建议干燥避光保存，避免反复冻融。