CD74, also known as Invariant chain (Ii) and p33, is a type 2 transmembrane glycoprotein that plays an important role in adaptive immunity, inflammation, and cancer. CD74 functions as a chaperone for MHC class II molecules on antigen presenting cells and undergoes progressive proteolysis during class II trafficking and antigenic peptide loading . Full length CD74 assembles into trimers which then associate with class II molecules in nonameric complexes on the cell surface. CD74 also associates with CD44 and binds with high affinity to the cytokine MIF, leading to inflammatory leukocyte responses, protection from tissue fibrosis, B cell proliferative and survival signaling, and the up‑regulation of angiogenic factors in endometrial stromal cells. MIF binding notably induces the proteolytic cleavage of the CD74 intracellular domain which then promotes B cell differentiation. CD74 is up‑regulated on non‑immune cells at sites of inflammation including amyloid beta plaques and atherosclerotic plaques . It is also up‑regulated in a variety of cancers and enhances tumorigenicity, tumor angiogenesis, and metastasis.

高纯度、高活性、低内毒素、高批间一致性

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-25 ~ -15℃保存，收到货之后有效期2年。 复溶后， 无菌条件下，-85 ~ -65℃保存，3个月有效期。