Zebularine (4-Deoxyuridine, NSC309132, NSC-309132),又称泽布拉林或2-嘧啶酮-B-核甙,一种胞苷类似物,最初是用作是胞苷脱氨酶抑制剂,Ki为2 μM。Zebularine是一种有效的DNA甲基转移酶抑制剂,但不是选择性抑制剂,与DNA甲基转移酶形成共价复合物。Zebularine可使超甲基化沉默的基因去甲基化和活化。
参考文献
1.Champion C, et al. Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine. PLoS One. 2010 Aug 24;5(8):e12388.
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4.Lemaire M, et al. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2'-deoxycytidine. Cancer Chemother Pharmacol. 2009 Feb;63(3):411-6.
冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。