JNJ-26489112是一款具有广谱抗惊厥活性的中枢神经系统活性剂，作用机制多元且对特定碳酸酐酶抑制作用较弱。它在啮齿类动物中能有效对抗音源性、电性和化学性惊厥，作用机制涉及抑制电压门控Na⁺通道、N型Ca²⁺通道，同时也是有效的K⁺通道开放剂；对碳酸酐酶CA-I和CA-II仅具有弱抑制活性，IC50分别为18μM和35μM。

[1] McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE. Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). J Med Chem. 2013 Nov 27;56(22):9019-30. doi: 10.1021/jm400894u. Epub 2013 Nov 11. PMID: 24205976; PMCID: PMC4004761.